Like all medicines, duloxetine can cause side effects in some people. But most people have no side effects or only minor ones.
Some of the common side effects of duloxetine will gradually improve as your body gets used to it.
Common side effects
杜洛西汀的这些常见副作用最多可以在十分之一的人中发生。您可以做一些事情来帮助他们应对：
Difficulty sleeping
Try taking duloxetine first thing in the morning.
头痛
Make sure you rest and drink plenty of fluids. Try not to drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.
Feeling dizzy
If duloxetine makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so you do not faint, then sit until you feel better. Do not drive, cycle or use tools or machinery if you feel dizzy.
Blurred vision
Avoid driving, cycling or using tools or machinery while this is happening. If it lasts for more than a day or two, your doctor may need to change your treatment.
Constipation
尝试将更多的纤维加入您的饮食中，例如新鲜水果，蔬菜和谷物，并喝大量的水。尝试更定期地锻炼，例如每天散步或跑步。
Diarrhoea
Drink lots of fluids, such as water or squash, to avoiddehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.
Do not take any other medicines to treat腹泻without speaking to a pharmacist or doctor.
If you服用避孕药，您患有严重的腹泻for more than 24 hours, your contraception may not protect you from pregnancy. Check the pill packet for advice.
Feeling or being sick (nausea or vomiting)
坚持简单的饭菜，不要吃丰富或辛辣的食物。确保您早上用一些食物服用Duloxetine。如果您生病以避免dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.
If you服用避孕药，你生病了, your contraception may not protect you from pregnancy. Check the pill packet for advice.
口干
Chew sugar-free gum or suck sugar-free sweets.
出汗
Try wearing loose clothing, use a strong anti-perspirant, and keep cool using a fan if possible. If this does not help, you may need to try a different type of antidepressant.
Tiredness
Do not drive, cycle or use tools or machinery if you're feeling this way. Try taking duloxetine 1 hour before bedtime. Cut down the amount of alcohol you drink as alcohol will make you feel more tired.
如果疲倦在2周后不会消失，请向您的医生寻求建议。
Less appetite than usual and weight loss
This side effect should get better as your body gets used to the medicine. It may also help to eat smaller meals more often and eat foods you really enjoy. If your appetite does not improve or you lose a lot of weight, ask your doctor for advice.
Feeling less interested in sex, or having problems keeping an erection or reaching orgasm
Speak to your doctor if you get this side effect and it does not go away.
Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.
Serious side effects
严重的副作用很少见，在100人中不到1人中发生。
Book an appointment with your doctor if you get changes in your periods, such as heavy bleeding, spotting or bleeding between periods.
Call a doctor or contact 111 straight away if you have:
- hallucinations (seeing or hearing things that are not real), or you become aggressive and angry
- feelings of euphoria, excessive enthusiasm or excitement, or feeling restless so that you cannot sit or stand still
- constant headaches, long-lasting confusion or weakness, or frequent muscle cramps – these can be signs of low sodium levels in your blood
- 眼睛的白色或皮肤的泛黄，尽管在棕色或黑色皮肤上可能不太明显 - 这些可能是肝脏问题的迹象
- eye pain or blurred vision
- black or red poo or blood in your vomit – these can be signs of bleeding from your gut
- coughed up blood or have blood in your pee
- bleeding from your gums, or bruises that appear without a reason or get bigger
Go to111.nhs.ukor call111.
Immediate action required:Call 999 or go to A&E now if you get:
- tightness in your chest or shortness of breath
- any heavy bleeding that you cannot stop, such as cuts or nosebleeds that do not stop within 10 to 15 minutes
- 痛苦的勃起持续超过2个小时 - 即使您没有做爱，也可能会发生这种情况
- thoughts about harming yourself or ending your life
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (过敏反应）到杜洛西汀。
Immediate action required:请致电999或立即访问A＆E，如果：
- 您会得到皮疹，可能包括发痒，红色，肿胀，起泡或剥皮
- you're wheezing
- 你的胸部或喉咙紧绷
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
Other side effects
These are not all the side effects of duloxetine. For a full list, see the leaflet inside your medicines packet.